株式会社Rhelixa（レリクサ）

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SERVICE

Next Generation Sequencing
Bioinformatics

Cloud-based Tool RIAS®
for Medical Life Science Research

COMPANY PROFILE

OVERVIEW

Company

Rhelixa, Inc.

Office / Lab

5F KDX Ginza East Bldg., 3-7-2, Chuo-ku, Irifune, Tokyo, Japan.

Foundation

Feb. 2015

business

Omics research and consulting services
Development and operation of cloud-based services

Certification

JIS Q 27001:2014(ISO/IEC 27001:2013)　MSA-IS-612

PARTNER

BUSINESS DATAas of Mar. 2023

Company

209company

Institute

303institute

Project

9529 project

MEMBER

MANAGEMENT

Representative Director, CEO/CTO (Founder)

Ryo Nakaki

Ryo Nakaki holds a Ph.D. in Engineering from Department of Genome Science, Research Center for Advanced Science and Technology, Tokyo University. Ryo specializes in the analysis of large-scale omics data, especially epigenomic analysis. Ryo is a councilor of the Japanese Society of Anti-Aging Medicine.

Director, CSO

Tomoyuki Matsuno

After graduating from Yokohama National University, Tomoyuki joined Mitsubishi Corporation, where he was in charge of global sales and trading of derivatives products. Then worked for a U.S. trading company before becoming CEO of Rhelixa.

Director, CFO

Ryota Kamiya

After graduating from Yokohama National University, Ryota joined Nippon Life Insurance Company, where he was engaged in corporate planning and management of group companies in the Asset Management Division. After joining Rhelixa,He reformed the company's internal systems and management infrastructure to take the company public.

ADVISER

Yukihiro Maru　(Ph.D.)

Established Leave a Nest Co., Ltd. in 2002. Engaged in the "knowledge production industry," creating new businesses by combining technologies and knowledge from various fields. Building one of the largest deep tech ecosystems in Asia, and working on solving global-scale challenges. Involved in the launch of numerous deep tech ventures, including Euglena Co., Ltd.

Hidekazu Yamada（MD.,PhD.）

Visiting Professor at Kinki University. President of the Japanese Society of Anti-Aging Medicine. Board Certified Dermatologist, Japanese Dermatological Association. Medical Specialist of the Japanese Society of Dermatology, Japanese Society of Allergology, and Japanese Society of Oriental Medicine. Founded the Kinki University Anti-Aging Center in 2007 and was Deputy Director of the Center and Professor of the Department of Dermatology at Kinki University Nara Hospital. He is involved in treatment, research, and clinical trials for controlling the aging rate and rejuvenation using biological age measurement technology. He is also a member of the Osaka Pavilion Promotion Committee for the Osaka-Kansai Expo 2025 and Director of Advanced Preventive Medicine in Healthcare.

Yasuharu Kanki　(M.D., Ph.D.)

Graduated from Kyoto University School of Medicine (M.D.). Obtained a Ph.D. from the Laboratory for Systems Biology and Medicine (LSBM) at the University of Tokyo's Research Center for Advanced Science and Technology. Has experience studying at the National Institutes of Health (NIH). Has numerous research publications on vascular epigenomics.

Co-authored Papers

Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids.
Sci Rep. 2023 Aug 9;13(1):12888. doi: 10.1038/s41598-023-40051-6.
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms.
Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721.
A de novo genome assembly of Solanum verrucosum Schlechtendal, a Mexican diploid species geographically isolated from other diploid A-genome species of potato relatives.
G3 (Bethesda). 2022 Jul 1:jkac166. doi: 10.1093/g3journal/jkac166. Online ahead of print.
Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis.
Cell Rep. 2022 Feb 8;38(6):110332. doi: 10.1016/j.celrep.2022.110332.
Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.
Nat Commun. 2021 Dec 2;12(1):7045. doi: 10.1038/s41467-021-27321-5.
Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction.
Sci Rep. 2021 Sep 21;11(1):18687. doi: 10.1038/s41598-021-98344-7.
PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation.
Sci Signal. 2021 Jan 26;14(667):eabb3616. doi: 10.1126/scisignal.abb3616.
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.
EMBO J. 2020 Mar e103949. doi.org/10.15252/embj.2019103949
Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells.
Cell Rep. 2019 Oct 1;29(1):162-175.e9. doi: 10.1016/j.celrep.2019.08.086.
A de novo genome assembly of Solanum verrucosum Schlechtendal, a Mexican diploid species geographically isolated from other diploid A-genome species of potato relatives.
G3 (Bethesda). 2022 Jul 1:jkac166. doi: 10.1093/g3journal/jkac166. Online ahead of print.
Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis.
Nat Commun. 2021 Dec 2;12(1):7045. doi: 10.1038/s41467-021-27321-5.
Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction.
Sci Rep. 2021 Sep 21;11(1):18687. doi: 10.1038/s41598-021-98344-7.
PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation.
Sci Signal. 2021 Jan 26;14(667):eabb3616. doi: 10.1126/scisignal.abb3616.
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.
EMBO J. 2020 Mar e103949. doi.org/10.15252/embj.2019103949
Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells.
Cell Rep. 2019 Oct 1;29(1):162-175.e9. doi: 10.1016/j.celrep.2019.08.086.
Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.
Epigenetics & Chromatin 12, 77 (2019). doi.org/10.1186/s13072-019-0319-0
ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data.
EMBO Rep. 2018 Dec;19(12):e46255. doi:10.15252/embr.201846255
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.
EMBO J. 2018 Jul 2;37(13). pii: e97723. doi: 10.15252/embj.201797723.
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.
Nat Commun. 2018 Apr 19;9(1):1566. doi: 10.1038/s41467-018-03868-8.
Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.
Sci Rep. 2018 Feb 28;8(1):3779. doi: 10.1038/s41598-018-22180-5.
NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.
Nat Cell Biol. 2017 Sep;19(9):1081-1092. doi: 10.1038/ncb3590.
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Nucleic Acids Res. 2017 May 5;45(8):4344-4358. doi: 10.1093/nar/gkx159.
Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Cell Rep. 2017 Feb 28;18(9):2228-2242. doi: 10.1016/j.celrep.2017.02.006.
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell. 2015 Nov 19;60(4):584-96. doi: 10.1016/j.molcel.2015.10.025.
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun. 2015 May 7;6:7052. doi: 10.1038/ncomms8052.