Our Philosophy

— Decoding Life, Creating Future —

While the prevalent notion of “genome” is established as the predetermined genetic information that one inherently possesses before birth, the discovery in which the activity of gene expression is altered through temporal and environmental-dependent factors without changing its nucleotide sequence has led to the study of a recently emerging field – epigenome. Most disease, especially cancer, are known to be caused by the accumulation of epigenetic abnormalities that is acquired through our daily-based activities, including smoking and drinking. Furthermore, the molecular mechanism of epigenome, like that of genome, is highly conserved throughout various organisms and provide imperative function for their survival. Hence, epigenome is not only important for human healthcare but also vital agriculture, forestry and fisheries.

Rhelixa’s core competence lies in providing machine learning softwares and screening techniques for epigenetic analysis that best fits the consumers’ needs.

In order to achieve efficient and effective epigenetic analysis, however, there needs to be a way to obtain comprehensive, large-scale genetic information. Next Generation Sequencer, as the most advance gene sequencing technology to date, is an indispensable tool for such use. Rhelixa has all the equipments, along with softwares, experts and the know-hows necessary for obtaining integrated data from next-generation sequencer and analyzing the epigenome based on customers’ needs. From assessing human and animal (e.g. pets) healthcare and disease progression to optimizating agricultural management, Rhelixa has been working on various projects to help elucidate the functional mechanism of epigenome.

Our Mission

  1. Create a de facto standard for epigenetic analysis platform
  2. Provide hands-on support from designing, experimenting and analyzing epigenetic-based research to help publish papers and make commercial products
  3. Develop our own screening techniques and products by applying new findings obtained through epigenome analysis

What we do

Using Next Generation Sequence-based epigenetic research and analysis, we provide the following three primary services:

【Experimental Analysis】
We conduct epigenome experiments with Next Generation Sequencer, including ATAC-Seq (defined below), to evaluate activity state of organisms’ genome affected by temporal and environmental factors. In addition, we provide services in assessing one genome pertaining to disease risk as well as analyzing metagenome which speaks for the environmental condition. Our company is also open to discussing customizable experiments requested by our customers.

ATAC-seq is able to identify the genome-wide open chromatin domain (DNA fragmentation due to the Tn5 Transposase) and analyze the binding domain of transcription factor. Starting from 5 x 10^4 cell number, this methodology is considered far more efficient compared to FAIRE-seq, and DNase-seq as it requires fewer steps.

We integrate diverse set of data obtained from epigenome experiments to clarify control factors that confer the maintenance and changes in specific cell state. We believe that it is necessary to obtain various data set including, but not limited to, expression of mRNA and non-coding RNA, DNA methylation, histone modification, binding of transcription regulatory factors, and higher order structure to extract useful information. Rhelixa, with its analytical expertise and strategies provides comprehensible data that is best suited for each customers.

Aside from the field of epigenome, we also analyze metagenomic/genomic data obtained from Next Generation Sequencing. For projects/research that require data other than genetic information, we conduct integrated analysis in assessing various information using our own machine learning algorithms.

【Information Analysis】
We integrate diverse set of data obtained from epigenome experiments to clarify control factors that confer the maintenance and changes in specific cell state. We believe that it is necessary to obtain various data set including, but not limited to, expression of mRNA and non-coding RNA, DNA methylation, histone modification, binding of transcription regulatory factors, and higher order structure to extract useful information. Rhelixa, with its analytical expertise and strategies provides comprehensible data that is best suited for each customers.

Aside from the field of epigenome, we also analyze metagenomic/genomic data obtained from Next Generation Sequencing. For projects/research that require data other than genetic information, we conduct integrated analysis in assessing various information using our own machine learning algorithms.

【Basic Research・R&D Support】
We provide hands-on support for R&D from experiment design to final output (e.g. publication, productization). For commercializing a product, we identify and evaluate the genetic/epigenetic condition for screening tests.

For developing new screening methodology, we will comprehensively perform global analysis using next generation sequencer to narrow down the factors that are affecting specific state, and establish a method to detect these changes. By narrowing down the factors of interest as a result, the developed screening technique can be provided with cheaper price and with less effort.

Our Vision

Upon the completion of Human Genome Project in 2003, sequencers capable of reading our genomic information has much advanced to the point that its cost is expected to be as low as $100 in the year of 2020. As a result, these devices that have been mainly used for assessing human health and personalized medicine, is now being extensively implemented for screening and R&D on various organisms.

On the other hand, however, the technology used for analyzing current genome and epigenome information remains within the scope of universities, research institutes, and enterprises that focus on basic research – not user-friendly to everyone.

We hope to create an environment where life information is utilized in every scene using our feasible platform for screening and analyzing epigenome/genome.